Serendipity: A Rare Discovery of Haemoglobin D-Iran in An Indian Female During Routine Antenatal Screening for ß-Thalassemia
Published: July 1, 2015 | DOI: https://doi.org/10.7860/JCDR/2015/.6142
Rittu Surjit Chandel, Abhishek Roy, Leela Gul Abichandani
1. Junior Resident, Department of Biochemistry, Grant Government Medical College and Sir J.J. Group of Hospitals, Mumbai, India
2. Junior Resident, Department of Biochemistry, Grant Government Medical College and Sir J.J. Group of Hospitals, Mumbai, India
3. Professor, Department of Biochemistry, Grant Government Medical College and Sir J.J. Group of Hospitals, Mumbai, India.
Correspondence
Dr. Abhishek Roy,
Junior Resident, Department of Biochemistry, Grant Government Medical College and Sir J.J. Group of Hospitals,
Byculla, Mumbai-400008, India.
Email: mail@abhishek.ro
Haemoglobin D is a rare form of haemoglobinopathy in homozygous form. However, the heterozygous form of the disease is clinically silent and relatively easier to find in North-West India, Pakistan and Iran. Haemoglobin D is sometimes found to be coexistent with Haemoglobin S and/or Thalassaemia leading to clinically significant conditions like sickle cell anaemia with mild to moderate splenomegaly. In India the more prevalent form is Haemoglobin D-Punjab (also known as Hb D- Los Angeles) which has a prevalence of 2% in Punjab and around 1% in Gujarat. However, the variant, Haemoglobin D- Iran is very rare in India in heterozygous as well as homozygous forms. This report is of a 36-year-old female, who visited for an antenatal check up. On analysing the blood sample using Agarose Gel Electrophoresis in Alkaline media, the migration of abnormal haemoglobin to haemoglobin S/D/G region was observed. Sickle cell solubility test was negative. On capillary electrophoresis, peak in the Haemoglobin D Zone was seen.
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